Sodium → HCID 20130635, compound

HRID 1252881Notes

Reaction equation

HRID 1252881 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([NH:15][C:16]([NH:18][C:19]2[CH2:20][S:21][CH2:22][C:23]=2[C:24]([O:26]C)=O)=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].[Na]>C(O)(C)C.CN(C)C=O>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:24](=[O:26])[C:23]3[CH2:22][S:21][CH2:20][C:19]=3[NH:18][C:16]2=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]

Participants

4

Reactant 2

HCID 5360545SodiumHCID 20130628Isopropyl 2-chloro-4-fluoro-5-{3-[4-(methoxycarbonyl)-2,5-dihydrothien-3-yl]ureido}-benzoate

Product 1

HCID 20130635HCID 20130635, compound

Reagents, catalysts & solvents 1

HCID 20197112Isopropanol dimethylformamideSolvent

Procedure

using isopropyl 2-chloro-4-fluoro-5-{3-[4-(methoxycarbonyl)-2,5-dihydrothien-3-yl]ureido}-benzoate with sodium isopropylate in an isopropanol/dimethylformamide mixture there is obtained isopropyl 2-chloro-4-fluoro-5-{1,2,5,7-tetrahydro-2,4-dioxothieno[3,4-d]pyrimidin-3(4H)-yl}-benzoate, m.p. 180°-183° C.,

Sources & evidence

ORD record
ord-752a7210352d437fa748d5e9e6ff3e4c
Source dataset
uspto-grants-1988_05
Patent number
US04746352

Reaction notes

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