Sodium → isopropyl 2-chloro-4-fluoro-5-{1,4,6,7-tetrahydro-2,4-dioxo-thieno[3,2-d]pyrimidin-3(2H)-yl}-benzoate

HRID 1252883Notes

Reaction equation

HRID 1252883 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([NH:15][C:16]([NH:18][C:19]2[CH2:23][CH2:22][S:21][C:20]=2[C:24](OC)=[O:25])=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].[Na]>C(O)(C)C.CN(C)C=O>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:24](=[O:25])[C:20]3[S:21][CH2:22][CH2:23][C:19]=3[NH:18][C:16]2=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:8])[CH3:9])=[O:5]

Participants

4

Reactant 2

HCID 5360545SodiumHCID 20130707Isopropyl 2-chloro-4-fluoro-5-{3-[2-(methoxycarbonyl)-4,5-dihydro-thien-3-yl]ureido}-benzoate

Product 1

HCID 20130696isopropyl 2-chloro-4-fluoro-5-{1,4,6,7-tetrahydro-2,4-dioxo-thieno[3,2-d]pyrimidin-3(2H)-yl}-benzoate

Reagents, catalysts & solvents 1

HCID 20197112Isopropanol dimethylformamideSolvent

Procedure

using isopropyl 2-chloro-4-fluoro-5-{3-[2-(methoxycarbonyl)-4,5-dihydro-thien-3-yl]ureido}-benzoate with sodium isopropylate in an isopropanol/dimethylformamide mixture there is obtained isopropyl 2-chloro-4-fluoro-5-{1,4,6,7-tetrahydro-2,4-dioxo-thieno[3,2-d]pyrimidin-3(2H)-yl}-benzoate, m.p. 252°-254° C.,

Sources & evidence

ORD record
ord-60b9c8d5843249afb76bfb14d39f15f0
Source dataset
uspto-grants-1988_05
Patent number
US04746352

Reaction notes

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