Sodium → HCID 20130582, compound

HRID 1252884Notes

Reaction equation

HRID 1252884 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([NH:15][C:16]([NH:18][C:19]([CH3:27])=[C:20]([C:22](OCC)=[O:23])[F:21])=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].[Na]>C(O)(C)C.CN(C)C=O>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:22](=[O:23])[C:20]([F:21])=[C:19]([CH3:27])[NH:18][C:16]2=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]

Participants

4

Reactant 2

HCID 5360545SodiumHCID 54323609HCID 54323609, compound

Product 1

HCID 20130582HCID 20130582, compound

Reagents, catalysts & solvents 1

HCID 20197112Isopropanol dimethylformamideSolvent

Procedure

using isopropyl 2-chloro-4-fluoro-5-{3-[2-(ethoxycarbonyl)-2-fluoro-1-methylvinyl]ureido}-benzoate with sodium isopropylate in an isopropanol/dimethylformamide mixture there is obtained isopropyl 2-chloro-4-fluoro-5-[3,6-dihydro-5-fluoro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-benzoate, 1H-NMR (CDCl3, 400 MHz) 9.99 ppm (s, 1H), 7.84 ppm (d, 1H), 7.37 ppm (d, 1H), 5.26 ppm (m, 1H), 2.18 ppm (d, 3H), 1.38 ppm (d, 3H), 1.36 ppm (d, 3H),

Sources & evidence

ORD record
ord-dfe1d8c392694581aab21cdf4ff3511f
Source dataset
uspto-grants-1988_05
Patent number
US04746352

Reaction notes

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