Sodium → HCID 20130631, compound

HRID 1252894Notes

Reaction equation

HRID 1252894 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([NH:15][C:16]([NH:18][C:19]2[O:20][CH2:21][CH2:22][C:23]=2[C:24]([O:26]CC)=O)=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].[Na]>C(O)(C)C.CN(C)C=O>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:24](=[O:26])[C:23]3[CH2:22][CH2:21][O:20][C:19]=3[NH:18][C:16]2=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]

Participants

4

Reactant 2

HCID 5360545SodiumHCID 20130711HCID 20130711, compound

Product 1

HCID 20130631HCID 20130631, compound

Reagents, catalysts & solvents 1

HCID 20197112Isopropanol dimethylformamideSolvent

Procedure

using isopropyl 2-chloro-4-fluoro-5-{3-[3-(ethoxycarbonyl)-4,5-dihydro-furan-2-yl]ureido}-benzoate with sodium isopropylate in an isopropanol/dimethylformamide mixture there is obtained isopropyl 2-chloro-4-fluoro-5-{1,2,5,6-tetrahydro-2,4-dioxo-furo[2,3-d]pyrimidin-3(4H)-yl}-benzoate, m.p. 213°-215° C.,

Sources & evidence

ORD record
ord-06b84fdabf874ed7a8cbb3fa6fab07a6
Source dataset
uspto-grants-1988_05
Patent number
US04746352

Reaction notes

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