Dimethyl Sulfate → HCID 20130609, compound

HRID 1252918Notes

Reaction equation

HRID 1252918 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[C:19]([F:22])=[C:18]([C:23]([F:26])([F:25])[F:24])[NH:17][C:16]2=[O:27])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].S(OC)(O[CH3:32])(=O)=O>CN(C)C=O>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[C:19]([F:22])=[C:18]([C:23]([F:24])([F:25])[F:26])[N:17]([CH3:32])[C:16]2=[O:27])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]

Participants

4

Reactant 2

HCID 6497Dimethyl SulfateHCID 21270733HCID 21270733, compound

Product 1

HCID 20130609HCID 20130609, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

using isopropyl 2-chloro-4-fluoro-5-[3,6-dihydro-5-fluoro-4-trifluoromethyl-2,6-dioxo-1(2H)-pyrimidinyl]-benzoate and dimethyl sulphate in dimethylformamide there is obtained isopropyl 2-chloro-4-fluoro-5-[3,6-dihydro-5-fluoro-3-methyl-4-trifluoromethyl-2,6-dioxo-1(2H)-pyrimidinyl]-benzoate, m.p. 66°-68° C.,

Sources & evidence

ORD record
ord-f9329e741894462fb7b26fa45eea2dae
Source dataset
uspto-grants-1988_05
Patent number
US04746352

Reaction notes

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