HCID 20130647, compound → HCID 20130675, compound

HRID 1252933Notes

Reaction equation

HRID 1252933 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[C:19]([CH2:22]Cl)=[C:18]([CH3:24])[N:17]([CH3:25])[C:16]2=[O:26])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]>C(O)(C)C>[CH:7]([O:6][C:4](=[O:5])[C:3]1[CH:10]=[C:11]([N:15]2[C:20](=[O:21])[C:19]([CH2:22][O:6][CH:7]([CH3:9])[CH3:8])=[C:18]([CH3:24])[N:17]([CH3:25])[C:16]2=[O:26])[C:12]([F:14])=[CH:13][C:2]=1[Cl:1])([CH3:9])[CH3:8]

Participants

3

Reactant 1

HCID 20130647HCID 20130647, compound

Product 1

HCID 20130675HCID 20130675, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

using isopropyl 2-chloro-4-fluoro-5-[5-chloromethyl-3,6-dihydro-3,4-dimethyl-2,6-dioxo-1(2H)-pyrimidinyl]-benzoate with isopropanol there is obtained isopropyl-2-chloro-4-fluoro-5-[3,6-dihydro-3,4-dimethyl-5-isopropoxymethyl-2,6-dioxo-1(2H)-pyrimidinyl]-benzoate, 1H-NMR (CDCl3, 400 MHz) 7.82 ppm (d, 1H), 7.32 ppm (d, 1H), 5.22 ppm (m, 1H), 4.45 ppm (d, 1H), 4.34 ppm (d, 1H), 3.69 ppm (m, 1H), 3.48 ppm (s, 3H), 2.44 ppm (s, 3H), 1.35 ppm (d, 6H), 1.21 ppm (d, 6H).

Sources & evidence

ORD record
ord-58a6b2d8efee4edcb06715f554367d3f
Source dataset
uspto-grants-1988_05
Patent number
US04746352

Reaction notes

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