Hydrochloric Acid → HCID 86742190, compound

HRID 1252975Notes

Reaction equation

HRID 1252975 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[Cl-].[Al+3].[Cl-].[Cl-].[C:9]([CH:13]1[C:18](=[O:19])[CH2:17][CH:16]([C:20]2([CH3:40])[CH:25]=[C:24]([CH3:26])[CH2:23][C:22]([CH:28]3[CH2:33][C:32](=[O:34])[CH:31]([C:35](=[O:38])[CH2:36][CH3:37])[C:30](=[O:39])[CH2:29]3)([CH3:27])[CH2:21]2)[CH2:15][C:14]1=[O:41])(=[O:12])[CH2:10][CH3:11].Cl>ClCCl>[C:1]([C:24]1([CH3:26])[CH2:23][C:22]([CH:28]2[CH2:29][C:30](=[O:39])[CH:31]([C:35](=[O:38])[CH2:36][CH3:37])[C:32](=[O:34])[CH2:33]2)([CH3:27])[CH2:21][C:20]([CH:16]2[CH2:15][C:14](=[O:41])[CH:13]([C:9](=[O:12])[CH2:10][CH3:11])[C:18](=[O:19])[CH2:17]2)([CH3:40])[CH2:25]1)(=[O:3])[CH3:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 86742191HCID 86742191, compound

Product 1

HCID 86742190HCID 86742190, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Acetyl chloride (0.3 ml) was added to a cooled, stirred suspension of aluminium chloride (1.5 g) and 1,3-bis (2-propionylcyclohexane-1,3-dione-5-yl) mesitylene (1.0 g) in dichloromethane (30 ml). Stirring was continued as the solution was allowed to come to room temperature and then for a further 15 hours. The solution was poured into dilute hydrochloric acid and the organic layer was separated, dried (Mg SO4) and evaporated to give 5-acetyl-1,3-bis(2-propionyl-cyclohexane-1,3-dione-5-yl)mesitylene (0.7 g, 65%) as a semi-crystalline foam.

Workup

  1. stirringStirring
  2. customto come to room temperature
  3. customthe organic layer was separated
  4. dry with materialdried (Mg SO4)
  5. customevaporated

Sources & evidence

ORD record
ord-7a734b44eb824702bf3114dcb6690c05
Source dataset
uspto-grants-1988_05
Patent number
US04746350

Reaction notes

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