(2,5-Dimethoxy-3,4-dimethylphenyl)methyl acetate → HCID 20137829, compound

HRID 1252984Notes

Reaction equation

HRID 1252984 reaction equation
C([O:4][CH2:5][C:6]1[C:7]([O:16][CH3:17])=[C:8]([CH3:15])[C:9]([CH3:14])=[C:10]([O:12][CH3:13])[CH:11]=1)(=O)C>CO.[OH-].[Na+]>[CH3:13][O:12][C:10]1[CH:11]=[C:6]([CH2:5][OH:4])[C:7]([O:16][CH3:17])=[C:8]([CH3:15])[C:9]=1[CH3:14]

Participants

4

Reactant 1

HCID 148394(2,5-Dimethoxy-3,4-dimethylphenyl)methyl acetate

Product 1

HCID 20137829HCID 20137829, compoundYield 4.4%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A solution of intermediate D (5.1 g, 0.21 mole) in 100 ml of methanol and 25 ml of 10% sodium hydroxide was refluxed for one hour, then poured into ice water. The resulting solid was collected by filtration and dried to give 1.8 g of 1,4-dimethoxy-2,3-dimethyl-5-hydroxymethylbenzene (intermediate E).

Workup

  1. filtrationThe resulting solid was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-fc5c1a741d4d42a6bf9eabfb14273127
Source dataset
uspto-grants-1988_05
Patent number
US04746607

Reaction notes

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