Sodium Hydroxide → HCID 20137892, compound

HRID 1252998Notes

Reaction equation

HRID 1252998 reaction equation
[P:1]([CH2:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([C:15]([O:17]C)=[O:16])[CH:10]=1)=[O:7])([OH:4])([OH:3])=[O:2].[OH-].[Na+]>>[P:1]([CH2:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([C:15]([OH:17])=[O:16])[CH:10]=1)=[O:7])([OH:3])([OH:4])=[O:2]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 20137881HCID 20137881, compound

Product 1

HCID 20137892HCID 20137892, compound

Procedure

A mixture of 377 mg of methyl 4-(α-phosphonoacetamido)-picolinate and 4.2 ml of 1N sodium hydroxide is heated at 80° for 10 minutes. The reaction mixture is cooled, filtered through Dowex 50-X8 resin and evaporated to dryness. Trituration with ethanol affords 4-(α-phosphonoacetamido)-picolinic acid, m.p. 249°-252° (dec).

Workup

  1. temperatureis heated at 80° for 10 minutes
  2. temperatureThe reaction mixture is cooled
  3. filtrationfiltered through Dowex 50-X8 resin
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-6167c1a3d402492bb166fbd25ffcdb80
Source dataset
uspto-grants-1988_05
Patent number
US04746653

Reaction notes

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