Ethyl 5-phenyl-6-(4-trifluoromethylphenyl)-pyridine-2-carboxylate → Methyl 5-Phenyl-6-(4-trifluoromethylphenyl)-pyridine-2-carboxylate

HRID 12530Notes

Reaction equation

HRID 12530 reaction equation
[C:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:23]([O:25][CH2:26]C)=[O:24])=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>OS(O)(=O)=O.CO>[C:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:23]([O:25][CH3:26])=[O:24])=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:21])([F:22])[F:20])=[CH:15][CH:14]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 68407826Ethyl 5-phenyl-6-(4-trifluoromethylphenyl)-pyridine-2-carboxylate2×

Product 1

HCID 59338840Methyl 5-Phenyl-6-(4-trifluoromethylphenyl)-pyridine-2-carboxylate

Reagents, catalysts & solvents 2

HCID 1118Sulfuric AcidCatalystHCID 887MethanolSolvent

Procedure

Following General Procedure E, ethyl 5-phenyl-6-(4-trifluoromethylphenyl)-pyridine-2-carboxylate (Compound 29, 103 mg, 0.28 mmol) and conc. H2SO4 (5 drops) in MeOH (5 ml) were reacted to produce the title compound as a white solid.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-3748fd020f36428fb4e075cc855cf526
Source dataset
uspto-grants-2010_06
Patent number
US07728014B2

Reaction notes

Loading…