5-Methoxytetralone → HCID 3532765, compound

HRID 1253007Notes

Reaction equation

HRID 1253007 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH2:5][CH2:6][CH2:7][C:8]2=O.Cl.[NH2:15][OH:16].C([O-])(=O)C.[Na+]>C(O)C.O>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH2:5][CH2:6][CH2:7][C:8]2=[N:15][OH:16]

Participants

6

Reactant 3

HCID 366205-MethoxytetraloneHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

Product 1

HCID 3532765HCID 3532765, compoundYield 97.7%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent2×

Procedure

In a mixture of 240 ml of ethanol and 80 ml of water were dispersed 50 g of 5-methoxytetralone, 20 g of hydroxylamine hydrochloride, and 56 g of sodium acetate, and the dispersion was heat-refluxed for 4 hours. After cooling to room temperature, the reaction mixture was poured into 400 ml of water. The precipitated crystals were collected by filtration and dried to obtain 53 g of 5-methoxytetralone oxime.

Workup

  1. temperaturethe dispersion was heat-refluxed for 4 hours
  2. filtrationThe precipitated crystals were collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-feb48e69f3b94d769c012641c9c91df1
Source dataset
uspto-grants-1988_05
Patent number
US04746602

Reaction notes

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