Water → 9-Chloro-7-[2-(2,4-di-t-amylphenoxy)butanoylamino]-6-hydroxy-1,5-benzodiazepin-2,4-dione

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Reaction Steps

In a mixture of 200 ml of water and 40 ml of isopropanol was dispersed 20 g of the 3-amino-4-chloro-2-nitro-6-[2-(2,4-di-t-amylphenoxy)butanoylamino]phenol prepared in (4) above, and 100 g of sodium hydrosulfite was slowly added to the dispersion while stirring and heating on a steam bath. After refluxing, the reaction mixture was concentrated, and the precipitated solid was collected by filtration, washed with water, and dried to provide 17 g of the desired compound.

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