反应详情

In a mixture of 200 ml of water and 40 ml of isopropanol was dispersed 20 g of the 3-amino-4-chloro-2-nitro-6-[2-(2,4-di-t-amylphenoxy)butanoylamino]phenol prepared in (4) above, and 100 g of sodium hydrosulfite was slowly added to the dispersion while stirring and heating on a steam bath. After refluxing, the reaction mixture was concentrated, and the precipitated solid was collected by filtration, washed with water, and dried to provide 17 g of the desired compound.

1. temperatureheating on a steam bath
2. temperatureAfter refluxing
3. concentrationthe reaction mixture was concentrated
4. filtrationthe precipitated solid was collected by filtration
5. washwashed with water
6. customdried