Imidazole → HCID 20138061, compound

HRID 1253021Notes

Reaction equation

HRID 1253021 reaction equation
Cl[CH2:2][CH2:3][CH:4]1[CH2:10][N:9]([CH3:11])[C:8](=[O:12])[C:7]2[CH:13]=[CH:14][CH:15]=[N:16][C:6]=2[CH2:5]1.[NH:17]1[CH:21]=[CH:20][N:19]=[CH:18]1>CN(C)C=O>[N:17]1([CH2:2][CH2:3][CH:4]2[CH2:10][N:9]([CH3:11])[C:8](=[O:12])[C:7]3[CH:13]=[CH:14][CH:15]=[N:16][C:6]=3[CH2:5]2)[CH:21]=[CH:20][N:19]=[CH:18]1

Participants

4

Reactant 2

HCID 795ImidazoleHCID 14155950HCID 14155950, compound

Product 1

HCID 20138061HCID 20138061, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
130 °C

Procedure

To a solution of 8-(2-chloroethyl)-6,7,8,9-tetrahydro-6-methyl-5H-pyrido[3,2-c]azepin-5-one in dimethylformamide (DMF) is added imidazole. The solution is heated to about 130° C. for several hr. DMF is removed by evaporation in vacuo and the residue is taken up in chloroform. The chloroform solution is washed with dilute aqueous sodium hydroxie, dried over anhydrous sodium sulfate and concentrated on a rotary evaporator to give the title compound.

Workup

  1. customDMF is removed by evaporation in vacuo
  2. washThe chloroform solution is washed with dilute aqueous sodium hydroxie
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated on a rotary evaporator

Sources & evidence

ORD record
ord-aede4aefc7e6417286769128a19a0fdb
Source dataset
uspto-grants-1988_05
Patent number
US04746657

Reaction notes

Loading…