Hydrochloric Acid → 3,4-dihydro-6-(3,4-dimethoxyphenyl)-1-ethyl-3-methyl-4-(2,4,6-trimethylphenylimino)-2(1H)-pyrimidinone hydrochloride

HRID 1253074Notes

Reaction equation

HRID 1253074 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[N:16]([CH2:17][CH3:18])[C:15](=[O:19])[N:14]([CH3:20])[C:13](=[N:21][C:22]3[C:27]([CH3:28])=[CH:26][C:25]([CH3:29])=[CH:24][C:23]=3[CH3:30])[CH:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[ClH:31]>O>[ClH:31].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[N:16]([CH2:17][CH3:18])[C:15](=[O:19])[N:14]([CH3:20])[C:13](=[N:21][C:22]3[C:23]([CH3:30])=[CH:24][C:25]([CH3:29])=[CH:26][C:27]=3[CH3:28])[CH:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 146868FK 664

Product 1

HCID 212432303,4-dihydro-6-(3,4-dimethoxyphenyl)-1-ethyl-3-methyl-4-(2,4,6-trimethylphenylimino)-2(1H)-pyrimidinone hydrochloride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a suspension of 3,4-dihydro-6-(3,4-dimethoxyphenyl)-1-ethyl-3-methyl-4-(2,4,6-trimethylphenylimino)-2(1H)-pyrimidinone (11.3 g) in water (20 ml) was added conc. hydrochloric acid (3.1 ml) and the mixture was evaporated under reduced pressure. To the residue was added ethanol (20 ml) and evaporated under reduced pressure again. The residue was crystallized from a mixture of diisopropyl ether and methanol (1:1) to give 3,4-dihydro-6-(3,4-dimethoxyphenyl)-1-ethyl-3-methyl-4-(2,4,6-trimethylphenylimino)-2(1H)-pyrimidinone hydrochloride (9.9 g).

Workup

  1. customthe mixture was evaporated under reduced pressure
  2. additionTo the residue was added ethanol (20 ml)
  3. customevaporated under reduced pressure again
  4. customThe residue was crystallized from a mixture of diisopropyl ether and methanol (1:1)

Sources & evidence

ORD record
ord-ce1ae26149844f68838ef709e8a2c3ae
Source dataset
uspto-grants-1988_05
Patent number
US04746664

Reaction notes

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