Formamide → Hydrochloric Acid

HRID 1253079Notes

Reaction equation

HRID 1253079 reaction equation
C([NH:3][CH:4]([C:6]1([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([Cl:17])[CH:11]=2)[CH2:9][CH2:8][CH2:7]1)[CH3:5])=O.C(N)=O>>[ClH:16].[Cl:17][C:12]1[CH:11]=[C:10]([C:6]2([CH:4]([NH2:3])[CH3:5])[CH2:9][CH2:8][CH2:7]2)[CH:15]=[CH:14][C:13]=1[Cl:16]

Participants

4

Reactant 2

HCID 713FormamideHCID 23292610N-formyl-1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine

Product 2

HCID 313Hydrochloric AcidHCID 130831401-[1-(3,4-Dichlorophenyl)cyclobutyl]ethylamine

Procedure

The preparation of N-formyl-1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine (m.p. 124°-125° C.) (Example 1(a) Formula I R1 =Me; R2 =H; R3 =H; R4 =CHO; R5 =4-Cl and R6 =3-Cl) described above was repeated and the product isolated by cooling the reaction mixture and collecting the solid produced by filtration. The formamide was then hydrolysed by concentrated hydrochloric acid in industrial methylated spirit to give the hydrochloride salt of 1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine.

Workup

  1. customthe product isolated
  2. temperatureby cooling the reaction mixture
  3. customcollecting the solid
  4. customproduced by filtration

Sources & evidence

ORD record
ord-2781a3ce920a43018ca4812790e465e7
Source dataset
uspto-grants-1988_05
Patent number
US04746680

Reaction notes

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