Trifluoroacetic acid → HCID 13752778, compound

HRID 1253099Notes

Reaction equation

HRID 1253099 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C@H:7]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([NH:17][C@H:18]([C@H:23]([CH2:25][C:26]([O:28][CH3:29])=[O:27])[OH:24])[CH2:19][CH:20]([CH3:22])[CH3:21])=[O:16])[CH3:14])=[O:11])[OH:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[C:37]([OH:43])([C:39]([F:42])([F:41])[F:40])=[O:38]>>[NH2:1][C@H:2]([C@H:7]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([NH:17][C@H:18]([C@H:23]([CH2:25][C:26]([O:28][CH3:29])=[O:27])[OH:24])[CH2:19][CH:20]([CH3:21])[CH3:22])=[O:16])[CH3:14])=[O:11])[OH:8])[CH2:3][CH:4]([CH3:5])[CH3:6].[F:40][C:39]([C:37]([OH:43])=[O:38])([F:42])[F:41]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 13384501HCID 13384501, compound

Product 1

HCID 13752778HCID 13752778, compound

Procedure

200 mg of Boc-Sta-Ala-Sta-OMe are treated with 3.5 ml of TFA at 0° C. The mixture is stirred for 20 min at RT. Then, after concentration in vacuo, the oily residued is extracted by successively adding and concentrating anhydrous ether. This gives a white solid.

Workup

  1. concentrationThen, after concentration in vacuo
  2. extractionthe oily residued is extracted
  3. additionby successively adding
  4. concentrationconcentrating anhydrous ether
  5. customThis gives a white solid

Sources & evidence

ORD record
ord-950452a3702b49b9843988c81d3b8a17
Source dataset
uspto-grants-1988_05
Patent number
US04746648

Reaction notes

Loading…