反应详情

A mixture of the 4-methoxy compound from Step 3 above (5 g) and 48% aq. HBr (50 ml) in glacial acetic acid (50 ml) is refluxed for three hours. The mixture is poured into H2O, the pH added to 8-10 and extracted with methylene chloride. The organic extract is washed with sat'd NaCl, dried, filtered, evaporated and the residue chromatographed (silica gel, hexane/ether) affording the desired product as a green solid.

1. temperatureis refluxed for three hours
2. additionthe pH added to 8-10
3. extractionextracted with methylene chloride
4. extractionThe organic extract
5. washis washed with sat'd NaCl
6. customdried
7. filtrationfiltered
8. customevaporated
9. customthe residue chromatographed (silica gel, hexane/ether)