Sodium Bicarbonate → HCID 131715543, compound

Participants

Reaction Steps

A mixture of p-nitrobenzyl (5R,6S)-2-ethylsulfinyl-6-methoxy-pen-2-em-3-carboxylate (48 mg, 0.12 mmol) and 10% pd/C (100 mg) in dioxane (8 ml) and H2O (4 ml) is shaken under a H2 pressure of 45 psi for 60 minutes. The reaction mixture is diluted with H2O (20 ml) containing NaHCO3 (10 mg, 0.12 mmol) and filtered to remove the catalyst. The filtrate is washed with Et2O (3×20 ml), concentrated under vacuum to ca. 5 ml volume, and lyophilized to provide the crude product.

Provenance & Evidence