Sodium Bicarbonate → HCID 131715543, Verbindung

HRID 1253162Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1253162
[CH2:1]([S:3]([C:5]1[S:6][C@@H:7]2[C@@H:24]([O:25][CH3:26])[C:23](=[O:27])[N:8]2[C:9]=1[C:10]([O:12]CC1C=CC([N+]([O-])=O)=CC=1)=[O:11])=[O:4])[CH3:2].C([O-])(O)=O.[Na+:32]>O1CCOCC1.O>[CH2:1]([S:3]([C:5]1[S:6][C@@H:7]2[C@@H:24]([O:25][CH3:26])[C:23](=[O:27])[N:8]2[C:9]=1[C:10]([O-:12])=[O:11])=[O:4])[CH3:2].[Na+:32]

Komponenten

5

Edukt 2

HCID 516892Sodium BicarbonateHCID 57039536HCID 57039536, Verbindung

Produkt 1

HCID 131715543HCID 131715543, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittel2×HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A mixture of p-nitrobenzyl (5R,6S)-2-ethylsulfinyl-6-methoxy-pen-2-em-3-carboxylate (48 mg, 0.12 mmol) and 10% pd/C (100 mg) in dioxane (8 ml) and H2O (4 ml) is shaken under a H2 pressure of 45 psi for 60 minutes. The reaction mixture is diluted with H2O (20 ml) containing NaHCO3 (10 mg, 0.12 mmol) and filtered to remove the catalyst. The filtrate is washed with Et2O (3×20 ml), concentrated under vacuum to ca. 5 ml volume, and lyophilized to provide the crude product.

Aufarbeitung

  1. filtrationfiltered
  2. customto remove the catalyst
  3. washThe filtrate is washed with Et2O (3×20 ml)
  4. concentrationconcentrated under vacuum to ca. 5 ml volume

Quellen und Nachweise

ORD-Eintrag
ord-f58b583133534c0a89fa401e090234c6
Quelldatensatz
uspto-grants-1988_05
Patentnummer
US04748162

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