Hydrochloric Acid → HCID 20137152, compound

HRID 1253168Notes

Reaction equation

HRID 1253168 reaction equation
[CH3:1][N:2]=[C:3]([NH2:16])[NH:4][C:5]1[CH:9]=[N:8][N:7]([CH2:10][CH2:11][CH2:12][CH2:13][C:14]#[N:15])[N:6]=1.Cl.[CH3:18][OH:19]>C(Cl)(Cl)Cl>[CH3:1][N:2]=[C:3]([NH2:16])[NH:4][C:5]1[CH:9]=[N:8][N:7]([CH2:10][CH2:11][CH2:12][CH2:13][C:14](=[NH:15])[O:19][CH3:18])[N:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 20137143HCID 20137143, compound

Product 1

HCID 20137152HCID 20137152, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 5-[4-(2-methylguanidino)-1,2,3-triazol-2-yl]valeronitrile (0.8 g.) in a mixture of chloroform (15 ml.) and MeOH (5 ml.) was saturated at 0° with hydrogen chloride gas and the mixture maintained at 0° for 3 days. The mixture was evaporated to dryness and the residue basified with cold sodium carbonate solution and extracted witn chloroform. The extract was dried and evaporated to give methyl 5-[4-(2-methylguanidino)1,2,3-triazol-2-yl]valerimidate as a yellow oil (1.07 g.).

Workup

  1. temperaturethe mixture maintained at 0° for 3 days
  2. customThe mixture was evaporated to dryness
  3. extractionextracted witn chloroform
  4. customThe extract was dried
  5. customevaporated

Sources & evidence

ORD record
ord-d789d1d77ee3467cba4d2a09bee25f8f
Source dataset
uspto-grants-1988_05
Patent number
US04748165

Reaction notes

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