Acetohydrazide → HCID 178485101, compound

HRID 1253169Notes

Reaction equation

HRID 1253169 reaction equation
[CH3:1][N:2]=[C:3]([NH2:18])[NH:4][C:5]1[CH:9]=[N:8][N:7]([CH2:10][CH2:11][CH2:12][CH2:13][C:14](=[NH:17])OC)[N:6]=1.[C:19]([NH:22][NH2:23])(=[O:21])[CH3:20]>CO>[C:19]([NH:22][NH:23][C:14](=[NH:17])[CH2:13][CH2:12][CH2:11][CH2:10][N:7]1[N:6]=[C:5]([NH:4][C:3]([NH2:18])=[N:2][CH3:1])[CH:9]=[N:8]1)(=[O:21])[CH3:20]

Participants

4

Reactant 2

HCID 14039AcetohydrazideHCID 20137152HCID 20137152, compound

Product 1

HCID 178485101HCID 178485101, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 5-[4-[2-methylguanidino)-1,2,3-triazol2-yl]valerimidate (1.0 g.) in MeOH (12 ml.) was treated with acethydrazide (0.22 g.) and the solution stirred for 18 nours. Evaporation of the solvent and trituration of the resioue with ether/EtOH gave N-acetylamino-5[4-(2-methylguanidino)-1,2,3-triazol-2-yl]valeramidine as a yellow sticky solid [0.54 g.) which was used without further purification.

Workup

  1. customEvaporation of the solvent and trituration of the resioue with ether/EtOH

Sources & evidence

ORD record
ord-ad5cbedd866444acaf8289d46b677549
Source dataset
uspto-grants-1988_05
Patent number
US04748165

Reaction notes

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