Ethyl isothiocyanate → HCID 53787466, compound

HRID 1253173Notes

Reaction equation

HRID 1253173 reaction equation
[NH2:1][C:2]1[CH:6]=[N:5][N:4]([CH2:7][CH2:8][CH2:9][CH2:10][C:11]#[N:12])[N:3]=1.[CH2:13]([N:15]=[C:16]=[S:17])[CH3:14]>C(#N)C>[CH2:13]([NH:15][C:16](=[S:17])[NH:1][C:2]1[CH:6]=[N:5][N:4]([CH2:7][CH2:8][CH2:9][CH2:10][C:11]#[N:12])[N:3]=1)[CH3:14]

Participants

4

Reactant 2

HCID 10966Ethyl isothiocyanateHCID 20137164HCID 20137164, compound

Product 1

HCID 53787466HCID 53787466, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 5-(4-amino-1,2,3-triazol-2-yl)valeronitrile (1.65 g.) in acetonitrile (6 ml.) was treated with ethylisothiocyanate (0.87 g.) and the solution stirred for 2.5 days then heated under reflux for 4.5 hours. Evaporation of the solvent gave 5-[4-(3-ethylthioureido)-1,2,3-triazol-2-yl]valeronitrile.

Workup

  1. temperaturethen heated
  2. temperatureunder reflux for 4.5 hours
  3. customEvaporation of the solvent

Sources & evidence

ORD record
ord-e82122b92bd14f68a638e6154bfec3c9
Source dataset
uspto-grants-1988_05
Patent number
US04748165

Reaction notes

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