Diflunisal → HCID 70413194, compound

HRID 1253177Notes

Reaction equation

HRID 1253177 reaction equation
[CH:1]1[C:6]([C:7]2[CH:8]=[CH:9][C:10]([F:14])=[CH:11][C:12]=2[F:13])=[CH:5][C:4]([C:15]([OH:17])=[O:16])=[C:3]([OH:18])[CH:2]=1.[NH:19]([CH2:21][C@@H:22]([C@H:24]([C@@H:26]([C@@H:28]([CH2:30][OH:31])[OH:29])[OH:27])[OH:25])[OH:23])[CH3:20]>C(O)C>[CH:1]1[C:6]([C:7]2[CH:8]=[CH:9][C:10]([F:14])=[CH:11][C:12]=2[F:13])=[CH:5][C:4]([C:15]([OH:17])=[O:16])=[C:3]([OH:18])[CH:2]=1.[NH:19]([CH2:21][C@@H:22]([C@H:24]([C@@H:26]([C@@H:28]([CH2:30][OH:31])[OH:29])[OH:27])[OH:25])[OH:23])[CH3:20]

Participants

4

Reactant 2

HCID 3059DiflunisalHCID 8567N-Methyl-D-glucamine

Product 1

HCID 70413194HCID 70413194, compoundYield 94.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
20 °C

Procedure

83 grams of diflunisal, dissolved in 500 ml ethanol, were added to an aqueous solution of 65 g meglumine, by stirring slowly and at room temperature (20° C.), and the reaction mixture was maintained under stirring for 4 hours until the reaction was complete. After cooling at 7° C., the resulting white precipitate was filtered and washed with small quantities of ethanol. After drying, 139 g of diflunisal meglumine were obtained as a white microcrystalline powder.

Workup

  1. temperaturethe reaction mixture was maintained
  2. stirringunder stirring for 4 hours until the reaction
  3. temperatureAfter cooling at 7° C.
  4. filtrationthe resulting white precipitate was filtered
  5. washwashed with small quantities of ethanol
  6. customAfter drying

Sources & evidence

ORD record
ord-1c4289061ed8424580a084aeff271b8b
Source dataset
uspto-grants-1988_05
Patent number
US04748174

Reaction notes

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