Carbon Dioxide → HCID 14638217, compound

HRID 1253180Notes

Reaction equation

HRID 1253180 reaction equation
Cl[C:2]1[C:7]2[O:8][CH2:9][C:10](=[O:12])[NH:11][C:6]=2[N:5]=[C:4]([CH3:13])[N:3]=1.[CH2:14]([O:16][C:17]([N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)=[O:18])[CH3:15].C(=O)=O>C(O)CCC>[CH2:14]([O:16][C:17]([N:19]1[CH2:20][CH2:21][N:22]([C:2]2[C:7]3[O:8][CH2:9][C:10](=[O:12])[NH:11][C:6]=3[N:5]=[C:4]([CH3:13])[N:3]=2)[CH2:23][CH2:24]1)=[O:18])[CH3:15]

Participants

5

Reactant 3

HCID 280Carbon DioxideHCID 84311-Piperazinecarboxylic acid, ethyl esterHCID 608089HCID 608089, compound

Product 1

HCID 14638217HCID 14638217, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture containing 1 g of 4-chloro-2-methyl-6,7-dihydro-8H-pyrimido[5,4-b][1,4]oxazin-7-one (Khim. Geterotsikl. Soed. 1976, 681), 10 ml of n-butanol and 1.58 g of 1-ethoxycarbonylpiperazine is refluxed under protection against moisture and carbon dioxide, then evaporated. The residue is triturated with water and the product precipitated at 0° to 4° C. is filtered, washed with water and ether and dried to give 1.4 g (87%) of product, m.p.: 197°-198° C.

Workup

  1. customevaporated
  2. customThe residue is triturated with water
  3. customthe product precipitated at 0° to 4° C.
  4. filtrationis filtered
  5. washwashed with water and ether
  6. customdried

Sources & evidence

ORD record
ord-5add787aee034512a3e6f1309a0cf981
Source dataset
uspto-grants-1988_05
Patent number
US04748175

Reaction notes

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