反应详情

50.2 g of potassium phthalimide are added to 61.2 g of 4-benzyl-2-chloromethylmorpholine [Synth. Com. 10, 59 (1980)] dissolved in 150 ml of abs. dimethylformamide and the mixture is boiled under stirring for 6 hours. After cooling, the crystals are filtered, washed with dimethylformamide and then with cold water and dried to give 68.95 g (76%) of the product, m.p.: 130°-132° C.

1. dissolutiondissolved in 150 ml of abs
2. temperatureAfter cooling
3. filtrationthe crystals are filtered
4. washwashed with dimethylformamide
5. dry with materialwith cold water and dried