Potassium Carbonate → 5-Isopropoxy-3-ethoxycarbonyl-4-methyl-1,2,3,4-tetrahydro-beta-carboline-1-carboxylic acid

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Reaction Steps

To a stirred solution of 27.25 g 2-amino-3(4-isopropoxyindole-3-yl)butanoic acid ethylester in 70 ml ethylacetate was added 9.99 g glyoxylic acid hydrate dissolved in 70 ml water. The mixture was adjusted to pH 4 (10% K2CO3 -solution) and further stirred at room temperature for 6 hours. The yellow precipitate was collected by filtration, washed with ethylacetate and dried.

Provenance & Evidence