Hydrochloric Acid → HCID 13561743, compound

HRID 1253275Notes

Reaction equation

HRID 1253275 reaction equation
[CH3:1][C:2]1([CH3:13])[CH2:6][CH2:5][O:4][C:3]1=[CH:7][N:8]1[CH:12]=[N:11][CH:10]=[N:9]1.Cl.C[OH:16]>>[CH3:1][C:2]1([CH3:13])[CH2:6][CH2:5][O:4][C:3]1([OH:16])[CH2:7][N:8]1[CH:12]=[N:11][CH:10]=[N:9]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 54017571HCID 54017571, compound

Product 1

HCID 13561743HCID 13561743, compoundYield 93%

Procedure

30 g (0.17 mole) of (3,3-dimethyl-tetrahydrofuran-2-ylidene)-(1,2,4-triazol-1-yl)-methane and 100 g of concentrated hydrochloric acid are stirred in 300 ml of methanol at room temperature for 4 hours. The reaction mixture is concentrated in vacuo, the residue is taken up in water, the pH value is adjusted to 7 to 8 with dilute sodium hydroxide solution and the mixture is extracted with methylene chloride. The organic phase is washed with water, dried over sodium sulphate and concentrated in vacuo. 30.7 g (93% of theory) of 3,3-dimethyl-2-hydroxy-2-(1,2,4-triazol-1-yl-methyl)-tetrahydrofuran of melting point 93°-95° C. are obtained. ##STR101##

Workup

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. extractionthe mixture is extracted with methylene chloride
  3. washThe organic phase is washed with water
  4. dry with materialdried over sodium sulphate
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-e26215defe744f2992144db7aef71c3f
Source dataset
uspto-grants-1988_05
Patent number
US04748249

Reaction notes

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