Hydrochloric Acid → HCID 14156196, compound

HRID 1253298Notes

Reaction equation

HRID 1253298 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH:9]([CH:18]([C:23]([O:25]C)=O)[C:19]([O:21][CH3:22])=[O:20])[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1.C[O-].[Na+].Cl>CO>[CH3:22][O:21][C:19]([CH:18]1[CH:9]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)[CH2:8][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[NH:1][C:23]1=[O:25])=[O:20]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 10942334Sodium MethoxideHCID 14787653HCID 14787653, compound

Product 1

HCID 14156196HCID 14156196, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution containing 11.97 (33.5 mmol) of [2-(2-aminophenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid, dimethyl ester and 9.2 ml of 25% sodium methoxide (40.2 mmol) in 80 ml of methanol was refluxed for 1.5 hours and cooled to room temperature. Excess 1M hydrochloric acid solution was then added and the resulting precipitated product was removed by filtration to give 9.18 g of pure material, melting point 217°-219° C.

Workup

  1. temperaturewas refluxed for 1.5 hours
  2. customthe resulting precipitated product
  3. customwas removed by filtration

Sources & evidence

ORD record
ord-2c2a8625c0b6410caf2e66bc09dd0853
Source dataset
uspto-grants-1988_05
Patent number
US04748239

Reaction notes

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