HCID 70046943, compound → HCID 70047231, compound

HRID 1253302Notes

Reaction equation

HRID 1253302 reaction equation
[OH:1][C@H:2]1[C@@H:8]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)[CH2:7][C:6]2[CH:17]=[CH:18][CH:19]=[CH:20][C:5]=2[NH:4][C:3]1=[O:21]>CCOCC>[OH:1][C@H:2]1[C@H:8]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=2)[CH2:7][C:6]2[CH:17]=[CH:18][CH:19]=[CH:20][C:5]=2[NH:4][C:3]1=[O:21]

Participants

3

Reactant 1

HCID 70046943HCID 70046943, compound

Product 1

HCID 70047231HCID 70047231, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Flash chromatography (LPS-1 silica gel, 70:30 hexanes-ethyl acetate) of the mother liquor resulting from the trituration from ether of the crude (cis)-3-hydroxy-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one (see example 2E) afforded the title trans isomer, melting point 168°-170° C.

Workup

  1. customafforded the title trans isomer, melting point 168°-170° C.

Sources & evidence

ORD record
ord-93922097a4984a2ab68ea65fbee2f2b3
Source dataset
uspto-grants-1988_05
Patent number
US04748239

Reaction notes

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