反应详情

Aluminum chloride (600 g, 4.50 mol) is added in portion to a cold (0°-10° C.) stirred solution of propionanilide (230 g, 1.54 mol) and of propionyl chloride (297 g, 3.2 mol) in carbon disulphide (600 ml). The reaction mixture is heated at reflux for 24 h. It is poured into a mixture of hydrochloric acid and crushed ice, and extracted with methylene chloride. The organic phase is washed with a 1% sodium hydrogen carbonate solution, with water, dried (Na2SO4) and filtered. Evaporation of the solvent under reduced pressure gives 1-(4'-propionamidophenyl)-propan-1-one (165 g, 0.8 mol, yield 52%) m.p. 154°-155° C.

1. temperatureThe reaction mixture is heated
2. temperatureat reflux for 24 h
3. customcrushed ice
4. extractionextracted with methylene chloride
5. washThe organic phase is washed with a 1% sodium hydrogen carbonate solution, with water
6. dry with materialdried (Na2SO4)
7. filtrationfiltered
8. customEvaporation of the solvent under reduced pressure