Hydrochloric Acid → 2-(4-Acetyl-2-n-propyl-3-hydroxyphenoxy)-2-(4-methoxyphenyl) acetic acid

Participants

Reaction Conditions

Reaction Steps

A mixture of 4.5 g of Ethyl 2-(4-acetyl-2-n-propyl-3-hydroxyphenoxy)-2-(4-methoxyphenyl)acetate and 150 ml of 1 Normal sodium hydroxide was stirred at 80° C. for 2 hours. The reaction mixture was then cooled, acidified with 1 Normal hydrochloric acid, extracted with ethyl acetate, treated with charcoal, filtered and concentrated to dryness to give an oily residue which was crystallized from EtOAc/hexane, yielding 0.9 g of product, melting point 154°-156° C.

Provenance & Evidence