反应详情

温度

80 °C

A mixture of 4.5 g of Ethyl 2-(4-acetyl-2-n-propyl-3-hydroxyphenoxy)-2-(4-methoxyphenyl)acetate and 150 ml of 1 Normal sodium hydroxide was stirred at 80° C. for 2 hours. The reaction mixture was then cooled, acidified with 1 Normal hydrochloric acid, extracted with ethyl acetate, treated with charcoal, filtered and concentrated to dryness to give an oily residue which was crystallized from EtOAc/hexane, yielding 0.9 g of product, melting point 154°-156° C.

1. temperatureThe reaction mixture was then cooled
2. extractionextracted with ethyl acetate
3. additiontreated with charcoal
4. filtrationfiltered
5. concentrationconcentrated to dryness
6. customto give an oily residue which
7. customwas crystallized from EtOAc/hexane