反应详情

Gutkowska, Acta Pol. Pharm. 30, 109-113 (1973), shows the reaction of N,N-bis(2-chloroethyl)-n-butylamine with phenylacetonitrile in the presence of 50% aqueous sodium hydroxide solution and benzyltriethylammonium chloride as catalyst to produce 1-n-butyl-4-cyano-4-phenylpiperidine hydrochloride (30% yield).