HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylacetonitrile → 1-n-Butyl-4-cyano-4-phenylpiperidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylacetonitrile | HCID 8794 | — |
| Reactant | N,N-Bis(2-chloroethyl)-1-butanamine | HCID 39224 | — |
| Catalyst | Sodium Hydroxide | HCID 14798 | — |
| Catalyst | Benzyl triethylammonium chloride | HCID 66133 | — |
| Product | 1-n-Butyl-4-cyano-4-phenylpiperidine hydrochloride | HCID 70407336 | 30% |
Reaction Steps
Gutkowska, Acta Pol. Pharm. 30, 109-113 (1973), shows the reaction of N,N-bis(2-chloroethyl)-n-butylamine with phenylacetonitrile in the presence of 50% aqueous sodium hydroxide solution and benzyltriethylammonium chloride as catalyst to produce 1-n-butyl-4-cyano-4-phenylpiperidine hydrochloride (30% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04748276 |
| Source dataset | uspto-grants-1988_05 |
| ORD ID | ord-9f0360ac7a134866b21b774dddbc54b8 |
| Source note | uspto-grants-1988_05 |