反应详情

温度

70 °C

Into a 500 ml 3-necked roundbottom flask, was placed a solution of proline (20.0 g, 174. mmol) in EtOH (100 ml). To the above was added thinyl chloride (40 ml). The resulting solution was heated to 70° C., with stirring, for 12 hours. The mixture was concentrated by evaporation. To afford ethyl prolinate that was used without further purification.

1. customInto a 500 ml 3-necked roundbottom flask, was placed
2. concentrationThe mixture was concentrated by evaporation