HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 67207576, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl 4-hydroxy-3,4-dihydro-1,5-naphthyridine-3-carboxylate | HCID 67207071 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | HCID 67207576 | HCID 67207576 | — |
Reaction Steps
Ethyl 4-hydroxy-3,4-dihydro-1,5-naphthyridine-3-carboxylate (1.8 g, 8.2 mmol) was dissolved in 4% aqueous sodium hydroxide (80 ml). The reaction mixture was heated to reflux for 4 hours, cooled to room temperature, and then adjusted to pH=4 with 2N hydrochloric acid. The reaction mixture was filtered to give 4-hydroxy-3,4-dihydro-1,5-naphthyridine-3-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08455477B2 |
| Source dataset | uspto-grants-2013_06 |
| ORD ID | ord-6208b97a707f4d3e9b183dca491b5fe4 |
| Source note | uspto-grants-2013_06 |