Hydrochloric Acid → HCID 67207576, compound

HRID 1253508Notes

Reaction equation

HRID 1253508 reaction equation
[OH:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][N:10]=2)[N:5]=[CH:4][CH:3]1[C:12]([O:14]CC)=[O:13].Cl>[OH-].[Na+]>[OH:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][N:10]=2)[N:5]=[CH:4][CH:3]1[C:12]([OH:14])=[O:13]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67207071Ethyl 4-hydroxy-3,4-dihydro-1,5-naphthyridine-3-carboxylate

Product 1

HCID 67207576HCID 67207576, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Ethyl 4-hydroxy-3,4-dihydro-1,5-naphthyridine-3-carboxylate (1.8 g, 8.2 mmol) was dissolved in 4% aqueous sodium hydroxide (80 ml). The reaction mixture was heated to reflux for 4 hours, cooled to room temperature, and then adjusted to pH=4 with 2N hydrochloric acid. The reaction mixture was filtered to give 4-hydroxy-3,4-dihydro-1,5-naphthyridine-3-carboxylic acid.

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 4 hours
  3. filtrationThe reaction mixture was filtered

Sources & evidence

ORD record
ord-6208b97a707f4d3e9b183dca491b5fe4
Source dataset
uspto-grants-2013_06
Patent number
US08455477B2

Reaction notes

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