反应详情

To a solution of 6-(ethoxycarbonyl)-5-hydroxy-1,8-naphthyridine-2-carboxylic acid (70 g, 270 mmol) in water (700 mL) was added potassium hydroxide (100 g, 560 mmol). The reaction mixture was heated to reflux. After 2 hours, the reaction mixture was cooled and acidified with hydrochloric acid (5 M) to pH 2.5. The yellow precipitates were filtered and washed with water and pyridine to afford 5-hydroxy-1,8-naphthyridine-2,6-dicarboxylic acid.

1. temperatureThe reaction mixture was heated to reflux
2. temperaturethe reaction mixture was cooled
3. customThe yellow precipitates
4. filtrationwere filtered
5. washwashed with water and pyridine