反应详情

To quinoline (500 ml) was added 5-hydroxy-1,8-naphthyridine-2,6-dicarboxylic acid (50 g, 340 mmol). The reaction mixture was heated to reflux. After 8 hours, the reaction mixture was cooled and concentrated in vacuo to afford 1,8-naphthyridin-4-ol.

1. temperatureThe reaction mixture was heated to reflux
2. temperaturethe reaction mixture was cooled
3. concentrationconcentrated in vacuo