5-Hydroxy-1,8-naphthyridine-2,6-dicarboxylic acid → HCID 178516463, compound

HRID 1253518Notes

Reaction equation

HRID 1253518 reaction equation
[OH:1][C:2]1[C:11](C(O)=O)=[CH:10][N:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6](C(O)=O)=[N:7]2>N1C2C(=CC=CC=2)C=CC=1>[N:9]1[C:8]2[C:3](=[CH:4][CH:5]=[CH:6][N:7]=2)[C:2]([OH:1])=[CH:11][CH:10]=1

Participants

3

Reactant 1

HCID 1785241395-Hydroxy-1,8-naphthyridine-2,6-dicarboxylic acid

Product 1

HCID 178516463HCID 178516463, compound

Reagents, catalysts & solvents 1

HCID 7047QuinolineSolvent

Procedure

To quinoline (500 ml) was added 5-hydroxy-1,8-naphthyridine-2,6-dicarboxylic acid (50 g, 340 mmol). The reaction mixture was heated to reflux. After 8 hours, the reaction mixture was cooled and concentrated in vacuo to afford 1,8-naphthyridin-4-ol.

Workup

  1. temperatureThe reaction mixture was heated to reflux
  2. temperaturethe reaction mixture was cooled
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-a4f02701fbec4e1494183cd36e7ee939
Source dataset
uspto-grants-2013_06
Patent number
US08455477B2

Reaction notes

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