1-Isopropylpiperazine → 2-(4-Fluorophenyl)-6-(4-isopropyl-piperazin-1-yl)-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine

HRID 1253595Notes

Reaction equation

HRID 1253595 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:18]3[CH:23]=[CH:22][N:21]=[N:20][CH:19]=3)=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[N:10]=2)[N:7]=1.[CH:24]([N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1)([CH3:26])[CH3:25]>C(O)CCCC>[F:17][C:14]1[CH:15]=[CH:16][C:11]([C:9]2[N:10]=[C:5]3[CH:4]=[CH:3][C:2]([N:30]4[CH2:31][CH2:32][N:27]([CH:24]([CH3:26])[CH3:25])[CH2:28][CH2:29]4)=[N:7][N:6]3[C:8]=2[C:18]2[CH:23]=[CH:22][N:21]=[N:20][CH:19]=2)=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 780131-IsopropylpiperazineHCID 593677016-Chloro-2-(4-fluorophenyl)-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine

Product 1

HCID 252047972-(4-Fluorophenyl)-6-(4-isopropyl-piperazin-1-yl)-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine

Reagents, catalysts & solvents 1

HCID 62761-PentanolSolvent

Conditions

Temperature
130 °C

Procedure

The mixture of 0.26 g (0.8 mmol) of 6-chloro-2-(4-fluorophenyl)-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine and 0.66 g (3.2 mmol) of 1-isopropylpiperazine in 6 ml of pentanol is heated in a sealed tube at 130° C. for 10 hours.

Sources & evidence

ORD record
ord-1882d5a043e24b6dba1e300dc7d0fffe
Source dataset
uspto-grants-2013_06
Patent number
US08455491B2

Reaction notes

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