HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1253596Generated: October 26, 2026
1-(2-Hydroxyethyl)piperazine → 2-{4-[2-(4-Fluorophenyl)-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazin-6-yl]piperazin-1-yl}ethanol
https://huagongshe.com/reaction/1253596
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-(2-Hydroxyethyl)piperazine | HCID 7677 | — |
| Reactant | 6-Chloro-2-(4-fluorophenyl)-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine | HCID 59367701 | — |
| Solvent | 1-Pentanol | HCID 6276 | — |
| Product | 2-{4-[2-(4-Fluorophenyl)-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazin-6-yl]piperazin-1-yl}ethanol | HCID 25226613 | — |
Reaction Steps
The mixture of 0.26 g (0.8 mmol) of 6-chloro-2-(4-fluorophenyl)-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine and 0.425 g (3.2 mmol) of 2-hydroxyethylpiperazine in 4 ml of pentanol is heated in a sealed tube at 130° C. for 32 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08455491B2 |
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| Source dataset | uspto-grants-2013_06 |
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| ORD ID | ord-da12b7295ea24bc4bcce3408243e9236 |
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| Source note | uspto-grants-2013_06 |
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