1-(2-Hydroxyethyl)piperazine → 2-{4-[2-(4-Fluorophenyl)-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazin-6-yl]piperazin-1-yl}ethanol

HRID 1253596Notes

Reaction equation

HRID 1253596 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:18]3[CH:23]=[CH:22][N:21]=[N:20][CH:19]=3)=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[N:10]=2)[N:7]=1.[OH:24][CH2:25][CH2:26][N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>C(O)CCCC>[F:17][C:14]1[CH:15]=[CH:16][C:11]([C:9]2[N:10]=[C:5]3[CH:4]=[CH:3][C:2]([N:30]4[CH2:31][CH2:32][N:27]([CH2:26][CH2:25][OH:24])[CH2:28][CH2:29]4)=[N:7][N:6]3[C:8]=2[C:18]2[CH:23]=[CH:22][N:21]=[N:20][CH:19]=2)=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 593677016-Chloro-2-(4-fluorophenyl)-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine

Product 1

HCID 252266132-{4-[2-(4-Fluorophenyl)-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazin-6-yl]piperazin-1-yl}ethanol

Reagents, catalysts & solvents 1

HCID 62761-PentanolSolvent

Conditions

Temperature
130 °C

Procedure

The mixture of 0.26 g (0.8 mmol) of 6-chloro-2-(4-fluorophenyl)-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine and 0.425 g (3.2 mmol) of 2-hydroxyethylpiperazine in 4 ml of pentanol is heated in a sealed tube at 130° C. for 32 hours.

Sources & evidence

ORD record
ord-da12b7295ea24bc4bcce3408243e9236
Source dataset
uspto-grants-2013_06
Patent number
US08455491B2

Reaction notes

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