N-Methylethylamine → 5-chloro-N-ethyl-N-methylpyrazine-2-carboxamide

HRID 1253617Notes

Reaction equation

HRID 1253617 reaction equation
[Cl:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[CH2:11]([NH:13][CH3:14])[CH3:12]>>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([N:13]([CH2:11][CH3:12])[CH3:14])=[O:10])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 12219N-MethylethylamineHCID 4654725-Chloropyrazinoic acid

Product 1

HCID 594833125-chloro-N-ethyl-N-methylpyrazine-2-carboxamideYield 81.4%

Procedure

The title compound (I-7a) was prepared by a method analogous to that described for the preparation of SM-1 using 5-chloropyrazine-2-carboxylic acid (2 g, 12.62 mmol) and ethyl-methyl-amine (0.846 g, 13.9 mmol) to afford the title compound 5-chloro-N-ethyl-N-methylpyrazine-2-carboxamide (SM-4: 2.05 g, 81%) as a clear oil

Workup

  1. customThe title compound (I-7a) was prepared by a method analogous to
  2. customthat described for the preparation of SM-1

Sources & evidence

ORD record
ord-1e0aab2bcd54469f8a5d5ac67521a902
Source dataset
uspto-grants-2013_06
Patent number
US08455496B2

Reaction notes

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