Hydrochloric Acid → HCID 66701244, compound

Participants

Reaction Steps

Hydrogen chloride in methanol (1.25 mol/l, 15.5 ml) was added to tent-butyl 9-(azetidin-1-yl)-3-azaspiro[5.5]undecane-3-carboxylate (1 g, 3.24 mmol) and the mixture was refluxed for 45 min. The solvent was removed in vacuo and the residue was dissolved in a small amount of ethanol. A solid was then precipitated out by addition of acetone, and finally diethyl ether was added and the precipitate formed was filtered out with suction. Yield: 0.87 g (95%)

Provenance & Evidence