Hydrochloric Acid → HCID 66701244, compound

HRID 1253665Notes

Reaction equation

HRID 1253665 reaction equation
[ClH:1].[N:2]1([CH:6]2[CH2:23][CH2:22][C:9]3([CH2:14][CH2:13][N:12](C(OCCCC)=O)[CH2:11][CH2:10]3)[CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3]1>CO>[ClH:1].[ClH:1].[N:2]1([CH:6]2[CH2:7][CH2:8][C:9]3([CH2:14][CH2:13][NH:12][CH2:11][CH2:10]3)[CH2:22][CH2:23]2)[CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131730608HCID 131730608, compound

Product 1

HCID 66701244HCID 66701244, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Hydrogen chloride in methanol (1.25 mol/l, 15.5 ml) was added to tent-butyl 9-(azetidin-1-yl)-3-azaspiro[5.5]undecane-3-carboxylate (1 g, 3.24 mmol) and the mixture was refluxed for 45 min. The solvent was removed in vacuo and the residue was dissolved in a small amount of ethanol. A solid was then precipitated out by addition of acetone, and finally diethyl ether was added and the precipitate formed was filtered out with suction. Yield: 0.87 g (95%)

Workup

  1. temperaturethe mixture was refluxed for 45 min
  2. customThe solvent was removed in vacuo
  3. dissolutionthe residue was dissolved in a small amount of ethanol
  4. customA solid was then precipitated out by addition of acetone, and finally diethyl ether
  5. additionwas added
  6. customthe precipitate formed
  7. filtrationwas filtered out with suction

Sources & evidence

ORD record
ord-896e5fa0fd014106be2aaa81437ec0eb
Source dataset
uspto-grants-2013_06
Patent number
US08455475B2

Reaction notes

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