反应详情

温度

0 °C

tert-Butyl 9-(pyridin-4-yloxy)-3-azaspiro[5.5]undecane-3-carboxylate (1 g, 2.886 mmol) was dissolved in methanol (2 ml), hydrogen chloride in methanol (1.25 mol/l, 11.5 ml) was added and the mixture was refluxed for 30 min. The solvent was removed in vacuo and the residue was dissolved in a small amount of ethanol. Acetone (approx. 25 ml) was subsequently added, the mixture was stirred at 0° C. for 30 min and the solid formed was finally filtered out with suction. Yield: 0.96 g (>99%)

1. temperaturethe mixture was refluxed for 30 min
2. customThe solvent was removed in vacuo
3. dissolutionthe residue was dissolved in a small amount of ethanol
4. additionAcetone (approx. 25 ml) was subsequently added
5. customthe solid formed
6. filtrationwas finally filtered out with suction