7379-35-3 → 7-(Pyridin-4-yl)-2,7-diazaspiro[3.5]nonane dihydrochloride

HRID 1253677Notes

Reaction equation

HRID 1253677 reaction equation
[CH2:1]1[C:4]2([CH2:9][CH2:8][NH:7][CH2:6][CH2:5]2)[CH2:3][N:2]1C(OC(C)(C)C)=O.[Cl-:17].[Cl:18][C:19]1[CH:24]=[CH:23][NH+:22]=[CH:21][CH:20]=1>>[ClH:18].[ClH:17].[N:22]1[CH:23]=[CH:24][C:19]([N:7]2[CH2:6][CH2:5][C:4]3([CH2:1][NH:2][CH2:3]3)[CH2:9][CH2:8]2)=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 108772907379-35-3HCID 23282935tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate

Product 1

HCID 675470657-(Pyridin-4-yl)-2,7-diazaspiro[3.5]nonane dihydrochloride

Procedure

The synthesis was carried out analogously to the synthesis of amine AMN-07. For this, in step (i) tert-butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate was reacted with 4-chloropyridinium chloride and in step (ii) the Boc protective group was split off in order to obtain the amine AMN-08.

Workup

  1. customwas split off in order

Sources & evidence

ORD record
ord-f556812706244fe1b7b608004876809f
Source dataset
uspto-grants-2013_06
Patent number
US08455475B2

Reaction notes

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