Acetyl chloride → (4-Methylpiperazin-1-yl)(3-azaspiro[5.5]undecan-9-yl)methanone hydrochloride

HRID 1253679Notes

Reaction equation

HRID 1253679 reaction equation
C([Cl:4])(=O)C.[CH3:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]([CH:14]2[CH2:31][CH2:30][C:17]3([CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]3)[CH2:16][CH2:15]2)=[O:13])[CH2:8][CH2:7]1>C(O)C>[ClH:4].[CH3:5][N:6]1[CH2:7][CH2:8][N:9]([C:12]([CH:14]2[CH2:31][CH2:30][C:17]3([CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)[CH2:16][CH2:15]2)=[O:13])[CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 67546380Tert-butyl 9-(4-methylpiperazine-1-carbonyl)-3-azaspiro[5.5]undecane-3-carboxylate

Product 1

HCID 66700938(4-Methylpiperazin-1-yl)(3-azaspiro[5.5]undecan-9-yl)methanone hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethanol (3 ml) and acetyl chloride (0.24 ml, 3.43 mmol) were added to tert-butyl 9-(4-methylpiperazine-1-carbonyl)-3-azaspiro[5.5]undecane-3-carboxylate (0.26 g, 0.685 mmol) and the mixture was stirred at room temperature for 12 h. When the reaction was complete, the solvent was removed in vacuo. Yield: 0.22 g (101%)

Workup

  1. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-8fcfe567d583432e96e937f67fb5033b
Source dataset
uspto-grants-2013_06
Patent number
US08455475B2

Reaction notes

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