Acetyl chloride → (4-Methylpiperazin-1-yl)(3-azaspiro[5.5]undecan-9-yl)methanone hydrochloride

Participants

Reaction Steps

Ethanol (3 ml) and acetyl chloride (0.24 ml, 3.43 mmol) were added to tert-butyl 9-(4-methylpiperazine-1-carbonyl)-3-azaspiro[5.5]undecane-3-carboxylate (0.26 g, 0.685 mmol) and the mixture was stirred at room temperature for 12 h. When the reaction was complete, the solvent was removed in vacuo. Yield: 0.22 g (101%)

Provenance & Evidence